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TOLERANCE
Tolerance to ENDONE may develop, which means that the effect of the medicine may decrease. If this happens, more may be needed to maintain the same effect.
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Continue taking your medicine for as long as your doctor tells you. If you stop taking this medicine suddenly, your pain may worsen and you may experience some or all of the following withdrawal symptoms:
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When you must not take it
Do not take ENDONE if you have an allergy to:
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Some of the symptoms of an allergic reaction may include:
- shortness of breath
- wheezing or difficulty breathing
- swelling of the face, lips, tongue or other parts of the body
- rash, itching or hives on the skin
Do not take this medicine if you are pregnant. It may affect your developing baby if you take it during pregnancy.
Do not breast-feed if you are taking this medicine. The active ingredient in ENDONE passes into breast milk and there is a possibility that your baby may be affected.
Do not give this medicine to children. Safety and effectiveness in children have not been established. ENDONE FOR SALE
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- a history of alcohol or drug abuse
- a history of mental illness
Do not take this medicine if you are taking or have taken medicines for depression called Monoamine Oxidase Inhibitors (MAOs) within the last 14 days.
Do not take this medicine after the expiry date printed on the pack or if the packaging is torn or shows signs of tampering. If it has expired or is damaged, return it to your pharmacist for disposal.
If you are not sure whether you should be taking this medicine, consult your doctor.
Before you start to take it
Tell your doctor if you have allergies to any other medicines, foods, preservatives or dyes.
Tell your doctor if you currently have or have had any of the following medical conditions:
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If you have not told your doctor about any of the above, tell them before you start taking ENDONE.
Taking other medicines
Tell your doctor or pharmacist if you are taking any other medicines, including any that you get without a prescription from your pharmacy, supermarket or health food shop.
Some medicines ENDONE may interfere with each other. These include:
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- medicines used to help lower blood pressure
- medicines used to treat anxiety
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- other medicines used to relieve pain
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These medicines may be affected by ENDONE or may affect how well it works. You may need different amounts of your medicines, or you may need to take different medicines.
Your doctor and pharmacist have more information on medicines to be careful with or avoid while taking this medicine.
How to take ENDONE
Follow all directions given to you by your doctor or pharmacist carefully. They may differ from the information contained in this leaflet.
If you do not understand the instructions on the box, ask your doctor or pharmacist for help.
How much to take
The usual dose is one tablet every six hours.
Your doctor may prescribe a different dose for you. Be sure to follow your doctor’s directions about when and how to take ENDONE.
How to take it
Swallow the tablets whole with a full glass of water.
When to take it
Take your medicine at about the same time each day. Taking it at the same time each day will have the best effect. It will also help you remember when to take it.
ENDONE should be taken after food or with milk.
How long to take it
Continue taking your medicine for as long as your doctor tells you.
If you have been using this medicine for a long period of time and it is no longer needed to manage your pain DO NOT stop taking ENDONE suddenly. Your doctor may want you to gradually reduce the amount of ENDONE you are taking before stopping completely in order to lessen the risk of withdrawal symptoms.
If you forget to take it
If it is less than 3 hours before your next dose, skip the dose you missed and take your next dose when you are meant to.
Otherwise, take it as soon as you remember, and then go back to taking your medicine as you would normally.
Do not take a double dose to make up for the dose that you missed. This may increase the chance of you getting an unwanted side effect.
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If you or someone else receives too much (overdose), and experience one or more of the symptoms below, immediately call triple zero (000) for an ambulance. Keep the person awake by talking to them or gently shaking them every now and then. You should follow the above steps even if someone other than you have accidentally used ENDONE that was prescribed for you. If someone takes an overdose, they may experience one or more of the following symptoms: BUY ENDONE 5MG
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Things you must do
If you are about to be started on any new medicine, remind your doctor and pharmacist that you are taking ENDONE.
Tell any other doctors, dentists and pharmacists who treat you that you are taking this medicine.
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Lorazepam, sold under the brand name Ativan among others, is a benzodiazepine medication.[3] It is used to treat anxiety disorders, trouble sleeping, severe agitation, active seizures including status epilepticus, alcohol withdrawal, and chemotherapy-induced nausea and vomiting.[3] It is also used during surgery to interfere with memory formation and to sedate those who are being mechanically ventilated.[3][7] It is also used, along with other treatments, for acute coronary syndrome due to cocaine use.[3] It can be given by mouth or as an injection into a muscle or vein.[3] When given by injection onset of effects is between one and thirty minutes and effects last for up buy ativan lorazepam australia to a day.[3]
Common side effects include weakness, sleepiness, low blood pressure, and a decreased effort to breathe.[3] When given intravenously the person should be closely monitored.[3] Among those who are depressed there may be an increased risk of suicide.[3][8] With long-term use, larger doses may be required for the same effect.[3] Physical dependence and psychological dependence may also occur.[3] If stopped suddenly after long-term use, benzodiazepine withdrawal syndrome may occur.[3] Older people more often develop adverse effects.[9] In this age group lorazepam is associated with falls and hip fractures.[10] Due to these concerns, lorazepam use is generally only recommended for up to two to four weeks.[11]
Lorazepam was initially patented in 1963 and went on sale in the United States in 1977.[12][13] It is on the World Health Organization’s List of Essential Medicines.[14] It is available as a generic medication.[3] In 2018, it was the 58th most commonly prescribed medication in the United States, with more than 13 million prescriptions buy ativan lorazepam australia
Medical uses
Anxiety
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Lorazepam is used in the short-term management of severe anxiety. In the US, the FDA advises against use of benzodiazepines such as lorazepam for longer than four weeks. [11][17] It is fast acting, and useful in treating fast onset panic anxiety. [18]
Lorazepam can effectively reduce agitation and induce sleep, and the duration of effects from a single dose makes it an appropriate choice for the short-term treatment of insomnia, especially in the presence of severe anxiety or night terrors. It has a fairly short duration of action. [19]
Withdrawal symptoms, including rebound insomnia and rebound anxiety, may occur after seven days’ use of lorazepam. [20]
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Intravenous diazepam or lorazepam are first-line treatments for convulsive status epilepticus. [21] Lorazepam is more effective than diazepam and intravenous phenytoin in the treatment of status epilepticus and has a lower risk of continuing seizures that might require additional medication. [22] However, phenobarbital has a superior success rate compared to lorazepam and other drugs, at least in the elderly. [23][24]
Lorazepam’s anticonvulsant properties and pharmacokinetic profile make intravenous use reliable for terminating acute seizures, but induce prolonged sedation. Oral benzodiazepines, including lorazepam, are occasionally used as long-term prophylactic treatment of resistant absence seizures; because of gradual tolerance to their anti-seizure effects, benzodiazepines such as lorazepam are not considered first-line therapies. [25]
Lorazepam’s anticonvulsant and CNS depressant properties are useful for the treatment and prevention of alcohol withdrawal syndrome. In this setting, impaired liver function is not a hazard with lorazepam, since lorazepam does not require oxidation, in the liver or otherwise, for its metabolism. [26][27]
Sedation
Lorazepam is sometimes used for individuals receiving mechanical ventilation. However, in critically ill people, propofol has been found to be superior to lorazepam both in effectiveness and overall cost; as a result, the use of propofol for this indication is now encouraged, whereas the use of lorazepam is discouraged. [28]
Its relative effectiveness in preventing new memory formation, [29] along with its ability to reduce agitation and anxiety, makes lorazepam useful as premedication. It is given before a general anesthetic to reduce the amount of anesthetic required, or before unpleasant awake procedures, such as in dentistry or endoscopies, to reduce anxiety, to increase compliance, and to induce amnesia for the procedure. Lorazepam by mouth is given 90 to 120 minutes before procedures, and intravenous lorazepam as late as 10 minutes before procedures. [30][31][32] Lorazepam is sometimes used as an alternative to midazolam in palliative sedation. [33] In intensive care units lorazepam is sometimes used to produce anxiolysis, hypnosis, and amnesia
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Drowsiness, dizziness, loss of coordination, headache, nausea, blurred vision, change in sexual interest/ability, constipation, heartburn, or change in appetite may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
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Do not take OxyContin tablets if you:
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Adults (over 18 years of age)
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are still in pain whilst taking these tablets discuss this with your doctor.
Do not exceed the dose recommended by your doctor.
You should check with your doctor or pharmacist if you are not sure.
Swallow your tablets whole with water.
Do not crush, dissolve or chew them.
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Oxycontin tablets also contain inactive ingredients including Hypromellose, butylated hydroxytoluene (BHT), polyethylene oxide, polyethylene glycol 400, titanium dioxide, and magnesium stearate. Additionally, 10 mg tablets also contain hydroxypropyl cellulose, 15 mg contain yellow iron oxide, black iron oxide, and red iron oxide, 20 mg contain red iron oxide and polysorbate, 30 mg contain red iron oxide, black iron oxide, yellow iron oxide, and polysorbate 80, 40 mg contain yellow iron oxide and polysorbate 80, 60 mg contain black iron oxide, red iron oxide, and polysorbate 80, and 80 mg contain yellow iron oxide, hydroxypropyl cellulose, indigo carmine aluminum lake, and FD & C Blue No. #2.
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Duromine 40 mg should be used as a part of an overall weight management plan which should include a medically controlled diet and exercise program.
Duromine is available only with a doctor’s prescription.
Your doctor may prescribe Duromine 40 mg for another purpose. If you are not sure why you are taking this medicine ask your doctor.
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When you must not take it
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Do not take Duromine if you have an allergy to:
any medicine containing phentermine
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swelling of the face, lips, tongue, or other parts of the body
rash, itching or hives on the skin
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Safety and effectiveness in children younger than 12 years have not been established.
Do not take this medicine if you have any of the following medical conditions:
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problems with the valves in your heart
disease related to blood vessels in the brain
severe heart disease including changes in the rhythm or rate of the heart beat
narrowing of the blood vessels due to thickening or hardening of the blood vessel wall
overactive thyroid gland
psychiatric illness including anorexia nervosa (loss of appetite) and depression
glaucoma (high pressure in the eye)
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Do not use this medicine:
if you are currently taking, or have taken within the last 14 days, antidepressant medicines from the mono-amine oxidase inhibitor (MAOI) class such as phenelzine (eg Nardil) or tranylcypromine (eg Parnate).
if you have previously misused drugs or alcohol
Do not take this medicine after the expiry date printed on the pack or if the packaging is torn or shows signs of tampering.
If it has expired or is damaged, return it to your pharmacist for disposal.
If you are not sure whether you should start taking this medicine, talk to your doctor.
Before you start to take it
Tell your doctor if you have allergies to any medicines, foods, preservatives or dyes.
Tell your doctor or pharmacist if you are pregnant or plan to become pregnant or are breast-feeding.
Your doctor or pharmacist can discuss with you the risks and benefits involved.
Taking other medicines
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Tell your doctor or pharmacist if you are taking any other medicines, including any that you get without a prescription from your pharmacy, supermarket or health food shop.
Some medicines and Duromine 40 mg may interfere with each other. These include:
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any medicines for depression or obsessive compulsive disorder such as fluoxetine (eg Prozac, Erocap, Lovan, Zactin); sertraline (eg, Zoloft); paroxetine (eg Aropax); clomipramine (eg Anafranil, Placil)
ergot-like medicines for migraine such as ergotamine (eg Cafergot, Ergodryl, Migral)
any cough and cold remedies containing pseudoephedrine, phenylpropanolamine or phenylephrine
thyroid hormones
any medication for mental illness
medicines for lowering high blood pressure including clonidine, methyldopa or guanethidine.
These medicines may be affected by Duromine 40 mg or may affect how well it works. You may need different amounts of your medicines, or you may need to take different medicines.
Your doctor and pharmacist have more information on medicines to be careful with or avoid while taking this medicine.
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Carefully follow all directions given to you by your doctor or pharmacist and never change the dose yourself.
They may differ from the information contained in this leaflet.
If you do not understand the instructions on the box, ask your doctor or pharmacist for help.
How much to take
In adults and adolescents over 12 years, the usual dose of Duromine is one capsule every day. However, your doctor will prescribe the right dose for you.
Increasing the dose may not necessarily make you lose more weight or make you lose weight faster. However you will most likely experience more side effects. Your doctor will tell you how long you are to take Duromine for.
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Swallow the capsules whole with plenty of water. Do not chew or open the capsules.
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Take Duromine first thing in the morning, at breakfast time so that it does not keep you awake at night.
Taking it at the same time each day will have the best effect. It will also help you remember when to take it.
It does not matter if you take this medicine before or after food.
Duromine 40 mg is not recommended for elderly patients or for children younger than twelve years.
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Take this medicine as long as your doctor tells you to.
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If you forget to take your Duromine dose at breakfast take it no later than lunchtime. Alternatively, skip the dose you missed and take your next dose at the normal time on the next day. If you take Duromine any later than lunch-time you may have trouble sleeping at night.
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Immediately telephone your doctor or the Poisons Information Centre (Australia: telephone 13 11 26; New Zealand: 0800 POISON or 0800 764 766) for advice, or go to Accident and Emergency at the nearest hospital, if you think that you or anyone else may have taken too much Duromine. Do this even if there are not signs of discomfort or poisoning.
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If you are about to be started on any new medicine remind your doctor and pharmacist that you are taking Duromine.
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It may interfere with the results of some tests.
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Do not take Duromine to treat any other complaints unless your doctor tells you to.
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Be careful driving or operating machinery until you know how Duromine affects you.
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Check with your doctor or pharmacist before you start to take any cough or cold medication.
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This medicine helps most people with a weight problem but it may have unwanted side effects in a few people. All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical attention if you get some of the side effects.
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